PARIS, GENEVA and BANGKOK September 5, 2018 – DBV Technologies (Euronext: DBV – ISIN: FR0010417345 – Nasdaq Stock Market: DBVT), the Geneva University Hospitals (HUG) and BioNet-Asia Co. Ltd presented new data from a Phase I study evaluating the safety and immunogenicity of boosting young adults against pertussis toxin (PT) with an investigational epicutaneous patch containing recombinant PT (Viaskin-PT). The new results, which were presented at the 5th European Congress of Immunology (ECI) in Amsterdam, Netherlands, September 2-5, 2018, by Dr. Olga Chatzis and Prof. Claire-Anne Siegrist from HUG, highlighted data from two additional cohorts showing that following skin preparation with an epidermal laser, anti-PT booster responses elicited by Viaskin-PT were comparable to those elicited by Boostrix? dTpa, an injectable approved booster vaccine. In March 2017, data from this study reported no detectable immunogenicity signal following the application of Viaskin-PT on intact skin.?
Data presented at ECI showed favorable safety and immunogenicity responses in healthy adults who received two applications of Viaskin-PT following skin preparation with an epidermal laser. No serious adverse events (SAEs) were reported. Most reported adverse events (AEs) were mild application-site reactions, and there were no AEs leading to study discontinuation. After the second application of Viaskin-PT, anti-PT IgG concentrations, which best correlate with a protective response against pertussis, were observed to be significantly higher in both Viaskin-PT cohorts (Viaskin-PT 25 -g, n=5, p
?We are excited by such strong immunogenicity results, which may be the result of the combination of a greater immunogen (recombinant PT) and a novel approach to vaccination and look forward to further exploring the use of this needle-less patch to boost immunity. We believe that the micro-pores created by the laser facilitate antigen entry in the epidermis, allowing for more antigen to be captured by lymph nodes and thus more effectively reactivate pertussis-specific memory cells. This represents an important next step in exploring the use of novel technologies for vaccination,? said Prof. Siegrist.
This Phase I proof of concept study was conducted under the supervision of Prof. Siegrist from the Clinical Research Center of HUG in collaboration with DBV Technologies and BioNet-Asia. The Company continues to evaluate these positive proof of concept results to determine potential next steps in vaccination.
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BioNet-Asia
Mr Laurent Dapremont
Director Strategic Business Development
E-mail: laurent.d@bionet-asia.com
Tel: +61 (04) 1362 0839
www.bionet-asia.com
